The definition of the toxicologically relevant applicability domain for the SNAr reaction for substituted pyridines and pyrimidines

This study outlines how results from a glutathione reactivity assay (so-called in chemico data) can be used to define the applicability domain for the nucleophilic aromatic substitution (S_NAr) reaction for nitrogen-containing aromatic compounds. S_NAr is one of the six mechanistic domains that have been shown to be important in toxicological endpoints in which the ability to bind covalently to a protein is a key molecular initiating event. This study has analysed experimental data (2 h RC₅₀ values), allowing a clear and interpretable structure–activity relationship to be developed for pyridines and pyrimidines which reside within the S_NAr domain. The in-ring nitrogen(s) act as activating groups in the S_NAr reaction. The position(s) of the in-ring nitrogen(s) as well as other activating groups, especially in relationship to the leaving group, affect reactive potency. The experimentally defined applicability domain has resulted in a series of structural alerts. These results build on early work on the benzene derivatives residing in the S_NAr domain. The definition of the applicability domain for the S_NAr reaction and the resulting structural alerts are likely to be beneficial in the development of computational tools for category formation and read-across in hazard identification, and the development of adverse outcome pathways.     

均衡信贷配给的期权定价分析

本文基于期权定价的视角分析信贷配给，以一条全新的思路阐释均衡信贷配给的成因及特征，并试图得出些许启示。     

确定模糊评价综合因素权重的一个方法

介绍引入三角模糊数判断矩阵以及将其转化为非模糊数判断矩阵的方法和步骤,说明它在确定模糊综合评价的因素权重时的作用和应用.最后进行实例分析.     

不确定型AHP中判断矩阵一致性的定义

文章定义了区间矩阵的几种运算，并给出了不确定型判断矩阵满足一致性的条件。     

高次退化的非线性向量场分支

本文讨论了一个在分支值线性部分具两个零特征根且只有一个Ｊｏｒｄａｎ块，而非线性项为５次的平面向量场，得到了完整的轨线分支图。本文引入的讨论判断函数性质的方法具有一般性，因而也将适用于具更高次退化的非线性情况的研究。     

基于矩阵初等变换的n元函数极值的快速判别法

给出了 n元函数极值的一个充分条件 ,并结合矩阵的初等变换建立了 n元函数极值的一种快速判别法 ,最后给出了一个例子     

混合判断矩阵排序方法研究

本文介绍了混合判断矩阵及完全一致性混合判断矩阵的概念，提出了混合判断矩阵排序的一种最小偏差法，并给出了其收敛性迭代算法，最后通过算例说明了方法的可行性。     

药物不良反应的特点与预防

药物不良反应已成为全社会关注的热点，及时了解有关不良反应的情况并采取必要的预防措施，以保证患者用药安全，维护患者身体健康是医务工作者刻不容缓的任务。     

普物实验教学应科学引导学生进行知能整合

以“电池电动势和内阻的测定”为例,简述了在普物实验教学中,科学引导学生进行知能整合的过程,使科学知识与相关知识的应用实现了最佳的整合,提高了学生设计实验、实验测量、科学评定实验过程及测量结果的能力。